Water → HCID 18757590、化合物

HRID 1020923ノート

反応式

HRID 1020923 の反応式
[F:1][C:2]1[C:8]([OH:9])=[C:7]([F:10])[CH:6]=[CH:5][C:3]=1[OH:4].[Cl:11][CH2:12][C:13](=O)[CH2:14][C:15](OCC)=[O:16].O>CS(O)(=O)=O>[Cl:11][CH2:12][C:13]1[C:5]2[C:3](=[C:2]([F:1])[C:8]([OH:9])=[C:7]([F:10])[CH:6]=2)[O:4][C:15](=[O:16])[CH:14]=1

参加物

5

反応物 3

HCID 962WaterHCID 69484Ethyl 4-chloroacetoacetateHCID 108445152,4-Difluororesorcinol

生成物 1

HCID 18757590HCID 18757590、化合物収率 25%

試薬・触媒・溶媒 1

HCID 6395Methanesulfonic Acid溶媒

実験手順

A solution of 2,4-difluororesorcinol (0.8 g) in 8 mL of methyl sulfonic acid is introduced into a flask and then 1.3 equivalents (963 μL) of ethyl 4-chloroacetoacetate are added dropwise. After 3 hours of stirring at room temperature, the mixture is cooled to 0° C. and then 100 mL of water are added. The residue is then filtered, dried and washed with diethyl ether in order to obtain 0.34 g (25%) of the compound 1.

後処理

  1. temperaturethe mixture is cooled to 0° C.
  2. filtrationThe residue is then filtered
  3. customdried
  4. washwashed with diethyl ether in order

出典と根拠

ORDレコード
ord-70ee8aa1047148cf8520ea0b6eb372a0
出典データセット
uspto-grants-2014_05
特許番号
US08716496B2

反応ノート

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