Hydrochloric Acid → 5-(1-methyl-1H-1,2,4-triazol-3-yl)-2-(1,2,3,6-tetrahydropyridin-4-yl)pyridine dihydrochloride

HRID 1020962ノート

反応式

HRID 1020962 の反応式
[ClH:1].[CH3:2][N:3]1[CH:7]=[N:6][C:5]([C:8]2[CH:9]=[CH:10][C:11]([C:14]3[CH2:19][CH2:18][N:17](C(OC(C)(C)C)=O)[CH2:16][CH:15]=3)=[N:12][CH:13]=2)=[N:4]1>O1CCOCC1.C(Cl)Cl>[ClH:1].[ClH:1].[CH3:2][N:3]1[CH:7]=[N:6][C:5]([C:8]2[CH:9]=[CH:10][C:11]([C:14]3[CH2:19][CH2:18][NH:17][CH2:16][CH:15]=3)=[N:12][CH:13]=2)=[N:4]1

参加物

5

反応物 2

HCID 313Hydrochloric AcidHCID 58371947Tert-butyl 4-(5-(1-methyl-1H-1,2,4-triazol-3-yl)pyridin-2-yl)-5,6-dihydropyridine-1(2H)-carboxylate

生成物 1

HCID 673440865-(1-methyl-1H-1,2,4-triazol-3-yl)-2-(1,2,3,6-tetrahydropyridin-4-yl)pyridine dihydrochloride

試薬・触媒・溶媒 2

HCID 6344Dichloromethane溶媒HCID 312751,4-Dioxane溶媒

実験手順

4M HCl in dioxane (20 ml) was added to a solution of Tert-butyl 4-(5-(1-methyl-1H-1,2,4-triazol-3-yl)pyridin-2-yl)-5,6-dihydropyridine-1(2H)-carboxylate (4BX) (4 g, 11.67 mmol) in CH2Cl2 (50 ml) at room temperature. The mixture was stirred for 3 hours then solvent was evaporated yielding title product as a white solid (3.8 g).

後処理

  1. customsolvent was evaporated

出典と根拠

ORDレコード
ord-14ba564c37044f01bca77ef1de068b0f
出典データセット
uspto-grants-2014_05
特許番号
US08716483B2

反応ノート

読み込み中…