Sodium Cyanide → 2-(2-Bromo-4-chlorophenyl)acetonitrile

HRID 1021350ノート

反応式

HRID 1021350 の反応式
[Br:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[CH2:9]Br.[C-:11]#[N:12].[Na+]>C(O)C.O>[Br:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[CH2:9][C:11]#[N:12]

参加物

5

反応物 2

HCID 8929Sodium CyanideHCID 106130662-Bromo-1-(bromomethyl)-4-chlorobenzene

生成物 1

HCID 218285012-(2-Bromo-4-chlorophenyl)acetonitrile収率 60.6%

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 962Water溶媒

実験手順

A mixture of 2-bromo-1-(bromomethyl)-4-chlorobenzene (9.8 g; 34.5 mmol) and sodium cyanide (2.0 g; 41.4 mmol) in 15 mL of 95% ethanol and 2.5 mL water was stirred and heated to reflux. After 30 minutes, the solvent was evaporated and the residue was partitioned between 100 mL ether and 50 mL water. The organic layer was dried over sodium sulfate and evaporated. The residual solid was washed out of the flask with hexane and collected by filtration, washed with hexane, and air-dried on the filter to give 4.82 g of 2-(2-bromo-4-chlorophenyl)acetonitrile as a light yellow solid.

後処理

  1. temperatureheated to reflux
  2. customthe solvent was evaporated
  3. customthe residue was partitioned between 100 mL ether and 50 mL water
  4. dry with materialThe organic layer was dried over sodium sulfate
  5. customevaporated
  6. washThe residual solid was washed out of the flask with hexane
  7. filtrationcollected by filtration
  8. washwashed with hexane
  9. customair-dried on the
  10. filtrationfilter

出典と根拠

ORDレコード
ord-32fdc4ae9d184e8cbc86b2a5508b876f
出典データセット
uspto-grants-2014_05
特許番号
US08716498B2

反応ノート

読み込み中…