M-Phenylenediamine → 3-(3-Aminophenylamino)-5-bromo-1-methylpyrazin-2(1H)-one
反応式
Br[C:2]1[C:3](=[O:10])[N:4]([CH3:9])[CH:5]=[C:6]([Br:8])[N:7]=1.[C:11]1([NH2:18])[CH:16]=[CH:15][CH:14]=[C:13]([NH2:17])[CH:12]=1.C(N(CC)CC)C>C(O)(C)C>[NH2:17][C:13]1[CH:12]=[C:11]([NH:18][C:2]2[C:3](=[O:10])[N:4]([CH3:9])[CH:5]=[C:6]([Br:8])[N:7]=2)[CH:16]=[CH:15][CH:14]=1参加物
5
反応条件
- 温度
- 80 °C
実験手順
To a solution of 3,5-dibromo-1-methylpyrazin-2(1H)-one (536 mg, 2.0 mmol) and benzene-1,3-diamine (324 mg, 3.0 mmol) in isopropanol (18 mL) was added triethylamine (2.8 mL). The reaction mixture was stirred at 80° C. overnight. Then the mixture was evaporated under reduced pressure to afford 219a (480 mg, 81%) as a white solid. MS-ESI: [M+H]+ 295.0
後処理
- customThen the mixture was evaporated under reduced pressure
出典と根拠
- ORDレコード
- ord-bab6a91f9c584c61847b4d7d79dbec94
- 出典データセット
- uspto-grants-2014_05
- 特許番号
- US08716274B2
反応ノート
読み込み中…