Hydrochloric Acid → (S)-6-Chloro-4-(5-(2-methylpiperazin-1-yl)pyridin-2-ylamino)pyridazin-3(2H)-one

HRID 1022073ノート

反応式

HRID 1022073 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([NH:17][C:18]2[N:23]=[CH:22][C:21]([N:24]3[CH2:29][CH2:28][N:27](C(OC(C)(C)C)=O)[CH2:26][C@@H:25]3[CH3:37])=[CH:20][CH:19]=2)[C:5](=[O:16])[N:6](COCC[Si](C)(C)C)[N:7]=1.Cl>CO>[Cl:1][C:2]1[CH:3]=[C:4]([NH:17][C:18]2[CH:19]=[CH:20][C:21]([N:24]3[CH2:29][CH2:28][NH:27][CH2:26][C@@H:25]3[CH3:37])=[CH:22][N:23]=2)[C:5](=[O:16])[NH:6][N:7]=1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 86684484(S)-tert-Butyl 4-(6-(6-Chloro-3-oxo-2-((2-(trimethylsilyl)ethoxy)-methyl)-2,3-dihydropyridazin-4-ylamino)pyridin-3-yl)-3-methylpiperazine-1-carboxylate

生成物 1

HCID 86684485(S)-6-Chloro-4-(5-(2-methylpiperazin-1-yl)pyridin-2-ylamino)pyridazin-3(2H)-one

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A 50-mL round-bottomed flask was charged with 253b (551 mg, 1.0 mmol), concentrated HCl (2 mL), and methanol (10 mL). The mixture was stirred at room temperature overnight. It was then concentrated under reduced pressure to afford 253c, which was used directly in the next step without further purification. MS-ESI: [M+H]+ 321.1

後処理

  1. concentrationIt was then concentrated under reduced pressure

出典と根拠

ORDレコード
ord-a213b18744604886bc160fe89d1fa00b
出典データセット
uspto-grants-2014_05
特許番号
US08716274B2

反応ノート

読み込み中…