Hydrazine → HCID 66975547、化合物
反応式
[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2([CH2:23][N:24]3C(=O)C4C(=CC=CC=4)C3=O)[O:15][CH2:14][CH2:13][N:12]([C:16]([O:18][C:19]([CH3:22])([CH3:21])[CH3:20])=[O:17])[CH2:11][CH2:10]2)[CH:5]=[CH:6][C:7]=1[Cl:8].NN>C(O)C>[NH2:24][CH2:23][C:9]1([C:4]2[CH:5]=[CH:6][C:7]([Cl:8])=[C:2]([Cl:1])[CH:3]=2)[O:15][CH2:14][CH2:13][N:12]([C:16]([O:18][C:19]([CH3:22])([CH3:21])[CH3:20])=[O:17])[CH2:11][CH2:10]1参加物
4
実験手順
To a solution of tert-butyl (7RS)-7-(3,4-dichlorophenyl)-7-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]-1,4-oxazepane-4-carboxylate (1.39 g) in ethanol (14 ml) was added hydrazine (2.8 ml), and the mixture was stirred at room temperature for 14 hr. The precipitate was removed by filtration, and the solvent of the filtrate was evaporated under reduced pressure. Water was added to the residue, and the mixture was extracted with ethyl acetate. The obtained extract was washed with water and brine, and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure to give the title compound (0.9 g).