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HRID 1022733作成日：2026年10月27日

tert-butyl (6R,7R)-6-(aminomethyl)-7-(4-chloro-3-fluorophenyl)-1,4-oxazepane-4-carboxylate → N-{[(6S,7R)-7-(4-chloro-3-fluorophenyl)-1,4-oxazepan-6-yl]methyl}-2-(pyridin-2-yloxy)acetamide monohydrochloride

https://huagongshe.com/reaction/1022733

反応式

関与物質

役割名称HCID仕込み量
反応物tert-butyl (6R,7R)-6-(aminomethyl)-7-(4-chloro-3-fluorophenyl)-1,4-oxazepane-4-carboxylateHCID 66975002—
反応物2-(2-Pyridyloxy)acetic acid hydrochlorideHCID 66975989—
生成物N-{[(6S,7R)-7-(4-chloro-3-fluorophenyl)-1,4-oxazepan-6-yl]methyl}-2-(pyridin-2-yloxy)acetamide monohydrochlorideHCID 66975109—

反応手順

Using tert-butyl (6R,7R)-6-(aminomethyl)-7-(4-chloro-3-fluorophenyl)-1,4-oxazepane-4-carboxylate and (pyridin-2-yloxy)acetic acid monohydrochloride, and by a method similar to that of Example 39, the title compound was obtained.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US08722662B2
出典データセットuspto-grants-2014_05
ORD IDord-ab769ca5a3844829884c6867cedabf14
出典メモuspto-grants-2014_05