2-(N-methyl-1-pyridin-2-ylformamido)acetic acid → N-[2-({[(6S,7R)-7-(4-chloro-3-fluorophenyl)-1,4-oxazepan-6-yl]methyl}amino)-2-oxoethyl]-N-methylpyridine-2-carboxamide monohydrochloride

HRID 1022739

反応式

HRID 1022739 の反応式
[NH2:1][CH2:2][C@H:3]1[C@H:9]([C:10]2[CH:15]=[CH:14][C:13]([Cl:16])=[C:12]([F:17])[CH:11]=2)[O:8][CH2:7][CH2:6][N:5](C(OC(C)(C)C)=O)[CH2:4]1.[CH3:25][N:26]([C:31]([C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][N:34]=1)=[O:32])[CH2:27][C:28](O)=[O:29]>>[ClH:16].[Cl:16][C:13]1[CH:14]=[CH:15][C:10]([C@@H:9]2[O:8][CH2:7][CH2:6][NH:5][CH2:4][C@H:3]2[CH2:2][NH:1][C:28](=[O:29])[CH2:27][N:26]([CH3:25])[C:31]([C:33]2[CH:38]=[CH:37][CH:36]=[CH:35][N:34]=2)=[O:32])=[CH:11][C:12]=1[F:17]

参加物

3

反応物 2

HCID 167761322-(N-methyl-1-pyridin-2-ylformamido)acetic acidHCID 66975002tert-butyl (6R,7R)-6-(aminomethyl)-7-(4-chloro-3-fluorophenyl)-1,4-oxazepane-4-carboxylate

生成物 1

HCID 66976522N-[2-({[(6S,7R)-7-(4-chloro-3-fluorophenyl)-1,4-oxazepan-6-yl]methyl}amino)-2-oxoethyl]-N-methylpyridine-2-carboxamide monohydrochloride

実験手順

Using tert-butyl (6R,7R)-6-(aminomethyl)-7-(4-chloro-3-fluorophenyl)-1,4-oxazepane-4-carboxylate and N-methyl-N-(pyridin-2-ylcarbonyl)glycine, and by a method similar to that of Example 39, the title compound was obtained.

出典と根拠

ORDレコード
ord-a3e4168c47bb4b72bcbde8de7c6bb3f4
出典データセット
uspto-grants-2014_05
特許番号
US08722662B2

関連ノート

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