化工社化工社 化学情報印刷レポート · 研究参考用
N-acetylanthranilic acid → 3-{[(6S,7R)-7-(4-chloro-3-fluorophenyl)-1,4-oxazepan-6-yl]methyl}-2-methylquinazolin-4(3H)-one monohydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | N-acetylanthranilic acid | HCID 6971 | — |
| 反応物 | tert-butyl (6R,7R)-6-(aminomethyl)-7-(4-chloro-3-fluorophenyl)-1,4-oxazepane-4-carboxylate | HCID 66975002 | — |
| 生成物 | 3-{[(6S,7R)-7-(4-chloro-3-fluorophenyl)-1,4-oxazepan-6-yl]methyl}-2-methylquinazolin-4(3H)-one monohydrochloride | HCID 66976700 | — |
反応手順
Using tert-butyl (6R,7R)-6-(aminomethyl)-7-(4-chloro-3-fluorophenyl)-1,4-oxazepane-4-carboxylate and 2-(acetylamino)benzoic acid, and by a method similar to that of Example 39, the title compound was obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08722662B2 |
| 出典データセット | uspto-grants-2014_05 |
| ORD ID | ord-752753948b8e49edab6ff8b64c1b4bbd |
| 出典メモ | uspto-grants-2014_05 |