1,2,4-Triazole-1-acetic acid → N-{[(6RS,7SR)-6-(3,4-dichlorophenyl)-1,4-oxazepan-7-yl]methyl}-2-(1H-1,2,4-triazol-1-yl)acetamide monohydrochloride

HRID 1022783

反応式

HRID 1022783 の反応式
[NH2:1][CH2:2][CH:3]1[O:9][CH2:8][CH2:7][N:6](C(OC(C)(C)C)=O)[CH2:5][CH:4]1[C:17]1[CH:22]=[CH:21][C:20]([Cl:23])=[C:19]([Cl:24])[CH:18]=1.[N:25]1([CH2:30][C:31](O)=[O:32])[CH:29]=[N:28][CH:27]=[N:26]1>>[ClH:23].[Cl:24][C:19]1[CH:18]=[C:17]([CH:4]2[CH:3]([CH2:2][NH:1][C:31](=[O:32])[CH2:30][N:25]3[CH:29]=[N:28][CH:27]=[N:26]3)[O:9][CH2:8][CH2:7][NH:6][CH2:5]2)[CH:22]=[CH:21][C:20]=1[Cl:23]

参加物

3

反応物 2

HCID 18101801,2,4-Triazole-1-acetic acidHCID 66975190tert-butyl (6RS,7SR)-7-(aminomethyl)-6-(3,4-dichlorophenyl)-1,4-oxazepane-4-carboxylate

生成物 1

HCID 66975689N-{[(6RS,7SR)-6-(3,4-dichlorophenyl)-1,4-oxazepan-7-yl]methyl}-2-(1H-1,2,4-triazol-1-yl)acetamide monohydrochloride

実験手順

Using tert-butyl (6RS,7SR)-7-(aminomethyl)-6-(3,4-dichlorophenyl)-1,4-oxazepane-4-carboxylate and 2-(1H-1,2,4-triazol-1-yl)acetic acid, and by a method similar to that of Example 39, step A and Example 449, step B, the title compound was obtained.

出典と根拠

ORDレコード
ord-711878dd5b7e48588d66498cd02cd52b
出典データセット
uspto-grants-2014_05
特許番号
US08722662B2

関連ノート

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