HCID 66976795、化合物 → HCID 66976282、化合物
反応式
[Cl:1][C:2]1[CH:3]=[C:4]([CH:9]2[CH:15](/[CH:16]=[CH:17]/[C:18]([O:20][CH2:21][CH3:22])=[O:19])[O:14][CH2:13][CH2:12][N:11]([C:23]([O:25][C:26]([CH3:29])([CH3:28])[CH3:27])=[O:24])[CH2:10]2)[CH:5]=[CH:6][C:7]=1[Cl:8]>C(O)C>[Cl:1][C:2]1[CH:3]=[C:4]([CH:9]2[CH:15]([CH2:16][CH2:17][C:18]([O:20][CH2:21][CH3:22])=[O:19])[O:14][CH2:13][CH2:12][N:11]([C:23]([O:25][C:26]([CH3:27])([CH3:29])[CH3:28])=[O:24])[CH2:10]2)[CH:5]=[CH:6][C:7]=1[Cl:8]参加物
3
実験手順
To a solution of tert-butyl (6SR,7RS)-6-(3,4-dichlorophenyl)-7-[(1E)-3-ethoxy-3-oxoprop-1-en-1-yl]-1,4-oxazepane-4-carboxylate (630 mg) in ethanol (5 ml) was added 3% Pt/sulfided carbon (100 mg), and the mixture was stirred under a hydrogen atmosphere at room temperature overnight. The catalyst was removed by filtration. The solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography to give the title compound (450 mg).
後処理
- customThe catalyst was removed by filtration
- customThe solvent was evaporated under reduced pressure
- custom