3-Chloro-2-hydroxypyridine → HCID 66976769、化合物

反応式

[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C@@H:8]2[O:14][CH2:13][CH2:12][N:11](C(OC(C)(C)C)=O)[CH2:10][C@H:9]2[CH2:22]OS(C)(=O)=O)=[CH:4][C:3]=1[F:28].[Cl:29][C:30]1[C:31](=[O:36])[NH:32][CH:33]=[CH:34][CH:35]=1>>[ClH:1].[Cl:29][C:30]1[C:31](=[O:36])[N:32]([CH2:22][C@H:9]2[C@H:8]([C:5]3[CH:6]=[CH:7][C:2]([Cl:1])=[C:3]([F:28])[CH:4]=3)[O:14][CH2:13][CH2:12][NH:11][CH2:10]2)[CH:33]=[CH:34][CH:35]=1

参加物

反応物 2

HCID 5822103-Chloro-2-hydroxypyridine

HCID 86663855tert-butyl (6S,7R)-7-(4-chloro-3-fluorophenyl)-6-{[(methylsulfonyl)oxy]methyl}-1,4-oxazepane-4-carboxylate

生成物 1

HCID 66976769HCID 66976769、化合物

実験手順

Using tert-butyl (6S,7R)-7-(4-chloro-3-fluorophenyl)-6-{[(methylsulfonyl)oxy]methyl}-1,4-oxazepane-4-carboxylate and 3-chloropyridin-2(1H)-one, and by a method similar to that in Example 31, steps C and E, the title compound was obtained.

出典と根拠

ORDレコード: ord-348be91966e848b3822d0b6619845f69
出典データセット: uspto-grants-2014_05
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08722662B2

反応ノート

読み込み中…