化工社化工社 化学情報印刷レポート · 研究参考用
Boron tribromide → 6-Hydroxy-4-(4,4,4-trifluoro-butyl)-isoquinoline
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Boron tribromide | HCID 25134 | — |
| 反応物 | 6-Methoxy-4-(4,4,4-trifluoro-butyl)-isoquinoline | HCID 57647053 | — |
| 反応物 | 6-Isoquinolinol, 7-bromo- | HCID 135854837 | — |
| 生成物 | 6-Hydroxy-4-(4,4,4-trifluoro-butyl)-isoquinoline | HCID 136092899 | 42.4% |
反応手順
1.02 g of 6-Methoxy-4-(4,4,4-trifluoro-butyl)-isoquinoline (87) were treated with boron tribromide as described for the synthesis of compound 1 to give 410 mg of the desired product 88. LCMS Method #1, retention time 1.04 min, detected mass 256.00 [M+H]+
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08722671B2 |
| 出典データセット | uspto-grants-2014_05 |
| ORD ID | ord-dd086d6d87324607b9f3a4aaf670a77a |
| 出典メモ | uspto-grants-2014_05 |