Dimethylformamide dimethyl acetal → 2-Chloro-N-dimethylaminomethylene-5-formyl-benzenesulfonamide
反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]=[O:9])=[CH:4][C:3]=1[S:10]([NH2:13])(=[O:12])=[O:11].CO[CH:16](OC)[N:17]([CH3:19])[CH3:18]>ClCCl>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]=[O:9])=[CH:4][C:3]=1[S:10]([N:13]=[CH:16][N:17]([CH3:19])[CH3:18])(=[O:12])=[O:11]参加物
4
実験手順
5.0 g (22.8 mmol) of 2-Chloro-5-formyl-benzenesulfonamide were dissolved in 50 ml of dichloromethane. 4.08 g (34.3 mmol) of dimethylformamide dimethylacetal were added and the mixture was refluxed for 2 h. After cooling to room temperature, the solution was washed twice with H2O, dried over magnesium sulfate and evaporated. 5.16 g of the crude product were obtained and used in the next step without further purification. Rt=1.14 min (Method #1). Detected mass: 275.1/277.1 (M+H+).