Potassium Carbonate → Piperazin-1-yl(thiazol-2-yl)methanone
反応式
FC(F)(F)C([N:5]1[CH2:10][CH2:9][N:8]([C:11]([C:13]2[S:14][CH:15]=[CH:16][N:17]=2)=[O:12])[CH2:7][CH2:6]1)=O.C([O-])([O-])=O.[K+].[K+]>CO.O>[N:8]1([C:11]([C:13]2[S:14][CH:15]=[CH:16][N:17]=2)=[O:12])[CH2:7][CH2:6][NH:5][CH2:10][CH2:9]1参加物
5
実験手順
A solution of compound 7a (3.8 g, 0.013 mol) and K2CO3 (3.5 g, 0.026 mol) in MeOH (40 mL) and water (10 mL), was stirred for 4 h. The solid was collected by filtration and the solvent evaporated in vacuo to give compound 7b (6.12 g). MS m/z (M+H+) 198.1.
後処理
- filtrationThe solid was collected by filtration
- customthe solvent evaporated in vacuo
出典と根拠
- ORDレコード
- ord-ffe586b4b5b14ee9bc1b14f9607b409e
- 出典データセット
- uspto-grants-2014_05
- 特許番号
- US08722658B2
反応ノート
読み込み中…