tert-butyl (2R)-2-hydroxypropanoate → tert-butyl (2S)-2-[4-chloro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]propanoate

反応式

[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[C:4]([B:9]2[O:13][C:12]([CH3:15])([CH3:14])[C:11]([CH3:17])([CH3:16])[O:10]2)[CH:3]=1.[C:18]([O:23][C:24]([CH3:27])([CH3:26])[CH3:25])(=[O:22])[C@@H:19]([CH3:21])O>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][C@@H:19]([CH3:21])[C:18]([O:23][C:24]([CH3:27])([CH3:26])[CH3:25])=[O:22])=[C:4]([B:9]2[O:13][C:12]([CH3:15])([CH3:14])[C:11]([CH3:17])([CH3:16])[O:10]2)[CH:3]=1

参加物

反応物 2

HCID 10953655tert-butyl (2R)-2-hydroxypropanoate

HCID 672770614-Chloro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol

生成物 1

HCID 67276583tert-butyl (2S)-2-[4-chloro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]propanoate

実験手順

The subtitle compound was prepared by the method of Example 2 step a) using the product from step e) and tert-butyl (R)-(+) lactate.

出典と根拠

ORDレコード: ord-413121448d3043c7bd0a765a7f097bdc
出典データセット: uspto-grants-2014_05
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08722741B2

反応ノート

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