4-Chlorobenzylamine → HCID 15982216、化合物

反応式

[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6][NH2:7])=[CH:4][CH:3]=1.CO[C:12]1[CH:20]=[CH:19][N:18]=[C:17]2[C:13]=1[CH:14]=CN2.[Cl:21][C:22]1[CH:30]=[CH:29][N:28]=[C:27]2[C:23]=1[CH:24]=[CH:25][NH:26]2>>[Cl:21][C:22]1[CH:30]=[CH:29][N:28]=[C:27]2[NH:26][CH:25]=[C:24]([CH2:14][C:13]3[CH:12]=[CH:20][C:19]([NH:7][CH2:6][C:5]4[CH:8]=[CH:9][C:2]([Cl:1])=[CH:3][CH:4]=4)=[N:18][CH:17]=3)[C:23]=12

参加物

反応物 3

HCID 660364-Chlorobenzylamine

HCID 112405674-Methoxy-1H-pyrrolo[2,3-b]pyridine

HCID 113894934-Chloro-1H-pyrrolo[2,3-b]pyridine

生成物 1

HCID 15982216HCID 15982216、化合物

実験手順

was prepared following the protocol of Scheme 12, substituting 4-trifluoro-benzylamine with 4-chloro-benzylamine in Step 1 and 4-methoxy-7-azaindole with 4-chloro-7-azaindole (24, prepared as described in Example 11) in Step 4. MS (ESI) [M+H+]+=381.1 and 383.0.

後処理

customwas prepared

出典と根拠

ORDレコード: ord-07eb6adf4857495caf6356212f75f0ad
出典データセット: uspto-grants-2014_05
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08722702B2

反応ノート

読み込み中…