関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Formaldehyde | HCID 712 | — |
| 反応物 | P-Chloroacetophenone | HCID 7467 | — |
| 反応物 | Dimethylamine, hydrochloride | HCID 10473 | — |
| 溶媒 | Acetone | HCID 180 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 1-Propanone, 1-(4-chlorophenyl)-3-(dimethylamino)-, hydrochloride (1:1) | HCID 200370 | 112% |
反応手順
To EtOH (80 mL), p-chloroacetophenone (77.3 g, 0.50 mol), dimethylamine hydrochloride (52.7 g, 0.65 mol), paraformaldehyde (19.8 g, 0.66 mol) and concentrated aqueous HCl (1 mL) were added and the mixture was refluxed for 5 h. The mixture was cooled to 40° C., acetone (400 mL) was added, and under stirring the mixture was cooled further to 20° C. The precipitate was filtered, washed with acetone and PA, and air dried to obtain 69.5 g of product which was used without further purification in the subsequent step.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08722887B2 |
|---|
| 出典データセット | uspto-grants-2014_05 |
|---|
| ORD ID | ord-5c99c52e2dd449b98ddccfd2181df25b |
|---|
| 出典メモ | uspto-grants-2014_05 |
|---|
