1-Isocyanato-2-phenoxybenzene → Methyl 3-methyl-2-(5-(4-(3-(2-phenoxyphenyl)ureido)phenyl)thiazole-2-carboxamido)butanoate

HRID 1024443

反応式

HRID 1024443 の反応式
[N:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[O:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)=[C:2]=[O:3].[CH3:17][CH:18]([CH3:41])[CH:19]([NH:24][C:25]([C:27]1[S:28][C:29]([C:32]2[CH:37]=[CH:36][C:35]([N+:38]([O-])=O)=[CH:34][CH:33]=2)=[CH:30][N:31]=1)=[O:26])[C:20]([O:22][CH3:23])=[O:21]>>[CH3:17][CH:18]([CH3:41])[CH:19]([NH:24][C:25]([C:27]1[S:28][C:29]([C:32]2[CH:37]=[CH:36][C:35]([NH:38][C:2]([NH:1][C:4]3[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=3[O:10][C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=3)=[O:3])=[CH:34][CH:33]=2)=[CH:30][N:31]=1)=[O:26])[C:20]([O:22][CH3:23])=[O:21]

参加物

3

反応物 2

HCID 27333891-Isocyanato-2-phenoxybenzeneHCID 67150324Methyl 3-methyl-2-(5-(4-nitrophenyl)thiazole-2-carboxamido)butanoate

生成物 1

HCID 52934597Methyl 3-methyl-2-(5-(4-(3-(2-phenoxyphenyl)ureido)phenyl)thiazole-2-carboxamido)butanoate収率 84%

実験手順

The title compound was synthesized analogous to Example 9, using 1-isocyanato-2-phenoxybenzene and intermediate 2. Yield: 84%; 1H NMR (DMSO-d6, 300 MHz): δ 9.53 (s, 1H), 8.73 (d, 1H), 8.54 (s, 1H), 8.35 (s, 1H), 8.27 (dd, 1H), 7.73 (d, 2H), 7.57 (d, 2H), 7.43 (dd, 2H), 7.17 (m, 1H), 7.1 (d, 1H), 7.07 (dd, 2H), 6.98 (d, 1H), 6.86 (d, 1H), 4.32 (m, 1H), 3.68 (s, 3H), 2.28 (m, 1H), 0.94 (d, 6H); MS (ES+) m/z 545 (M+1).

出典と根拠

ORDレコード
ord-7d1cf01104c943ce83ca78558b242620
出典データセット
uspto-grants-2014_05
特許番号
US08722901B2

関連ノート

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