4-Pentylbenzoyl chloride → Methyl 3-methyl-2-(N-methyl-5-(4-(4-pentylbenzamido)phenyl)thiazole-2-carboxamido)butanoate

HRID 1024457

反応式

HRID 1024457 の反応式
[CH2:1]([C:6]1[CH:14]=[CH:13][C:9]([C:10](Cl)=[O:11])=[CH:8][CH:7]=1)[CH2:2][CH2:3][CH2:4][CH3:5].[CH3:15][CH:16]([CH3:40])[CH:17]([N:22]([CH3:39])[C:23]([C:25]1[S:26][C:27]([C:30]2[CH:35]=[CH:34][C:33]([N+:36]([O-])=O)=[CH:32][CH:31]=2)=[CH:28][N:29]=1)=[O:24])[C:18]([O:20][CH3:21])=[O:19]>>[CH3:15][CH:16]([CH3:40])[CH:17]([N:22]([CH3:39])[C:23]([C:25]1[S:26][C:27]([C:30]2[CH:31]=[CH:32][C:33]([NH:36][C:10](=[O:11])[C:9]3[CH:13]=[CH:14][C:6]([CH2:1][CH2:2][CH2:3][CH2:4][CH3:5])=[CH:7][CH:8]=3)=[CH:34][CH:35]=2)=[CH:28][N:29]=1)=[O:24])[C:18]([O:20][CH3:21])=[O:19]

参加物

3

反応物 2

HCID 1708124-Pentylbenzoyl chlorideHCID 67150337Methyl 3-methyl-2-(N-methyl-5-(4-nitrophenyl)thiazole-2-carboxamido)butanoate

生成物 1

HCID 52935490Methyl 3-methyl-2-(N-methyl-5-(4-(4-pentylbenzamido)phenyl)thiazole-2-carboxamido)butanoate収率 59%

実験手順

The title compound was synthesized analogous to Example 27, using 4-pentylbenzoyl chloride and intermediate 4. Yield: 59%; 1H NMR (DMSO-d6, 300 MHz): δ 10.38 (s, 1H), 8.86 (d, 1H), 7.95 (m, 4H), 7.78 (d, 2H), 7.37 (d, 2H), 6.27-4.76 (d, 1H), 3.68 (s, 3H), 3.47-2.95 (s, 3H), 2.68 (t, 2H), 2.38 (m, 1H), 1.63 (m, 2H), 1.30 (m, 4H), 1.03 (m, 3H), 0.90 (dd, 6H); MS (ESI) m/z 522.2 [M+H]+.

出典と根拠

ORDレコード
ord-fd412049de1444eb9e8c51590d90fac0
出典データセット
uspto-grants-2014_05
特許番号
US08722901B2

関連ノート

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