4-tert-Butylbenzoyl chloride → Methyl 2-(5-(4-(4-tert-butylbenzamido)phenyl)-N-methylthiazole-2-carboxamido)-3-methylbutanoate

HRID 1024458

反応式

HRID 1024458 の反応式
[C:1]([C:5]1[CH:13]=[CH:12][C:8]([C:9](Cl)=[O:10])=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2].[CH3:14][CH:15]([CH3:39])[CH:16]([N:21]([CH3:38])[C:22]([C:24]1[S:25][C:26]([C:29]2[CH:34]=[CH:33][C:32]([N+:35]([O-])=O)=[CH:31][CH:30]=2)=[CH:27][N:28]=1)=[O:23])[C:17]([O:19][CH3:20])=[O:18]>>[C:1]([C:5]1[CH:13]=[CH:12][C:8]([C:9]([NH:35][C:32]2[CH:33]=[CH:34][C:29]([C:26]3[S:25][C:24]([C:22]([N:21]([CH:16]([CH:15]([CH3:39])[CH3:14])[C:17]([O:19][CH3:20])=[O:18])[CH3:38])=[O:23])=[N:28][CH:27]=3)=[CH:30][CH:31]=2)=[O:10])=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2]

参加物

3

反応物 2

HCID 743724-tert-Butylbenzoyl chlorideHCID 67150337Methyl 3-methyl-2-(N-methyl-5-(4-nitrophenyl)thiazole-2-carboxamido)butanoate

生成物 1

HCID 52935706Methyl 2-(5-(4-(4-tert-butylbenzamido)phenyl)-N-methylthiazole-2-carboxamido)-3-methylbutanoate収率 56%

実験手順

The title compound was synthesized analogous to Example 27, using 4-tert-butylbenzoyl chloride and intermediate 4. Yield: 56%; 1H NMR (DMSO-d6, 300 MHz): δ 10.38 (s, 1H), 8.37 (s, 1H), 8.04 (m, 4H), 7.78 (d, 2H), 7.57 (d, 2H), 6.27-4.76 (d, 1H), 3.69 (s, 3H), 3.47-2.95 (s, 3H), 2.35 (m, 1H), 1.33 (s, 9H), 1.11 (bs, 3H), 0.90 (bs, 3H); MS (ESI): m/z 508.2 [M+H]+.

出典と根拠

ORDレコード
ord-efb3820fee60420d8c503bc43f1c9074
出典データセット
uspto-grants-2014_05
特許番号
US08722901B2

関連ノート

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