化工社化工社 化学情報印刷レポート · 研究参考用
Methyl 4-(3-cyanopentan-3-yl)benzoate → Methyl 2-(5-(4-(4-(3-cyanopentan-3-yl)benzamido)phenyl)thiazole-2-carboxamido)-3-methylbutanoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methyl 4-(3-cyanopentan-3-yl)benzoate | HCID 67150320 | — |
| 反応物 | Methyl 3-methyl-2-(5-(4-nitrophenyl)thiazole-2-carboxamido)butanoate | HCID 67150324 | — |
| 生成物 | Methyl 2-(5-(4-(4-(3-cyanopentan-3-yl)benzamido)phenyl)thiazole-2-carboxamido)-3-methylbutanoate | HCID 52934136 | — |
反応手順
The title compound was synthesized analogous to Example 85, using methyl 4-(3-cyanopentan-3-yl)benzoate (Intermediate 6) and intermediate 2. 1HNMR (DMSO-d6, 300 MHz) δ 10.52 (s, 1H), 8.78 (d, 1H), 8.41 (s, 1H), 8.03 (d, 2H), 7.93 (d, 2H), 7.81 (d, 2H), 7.62 (d, 2H), 4.33 (m, 1H), 3.68 (s, 3H), 2.26 (m, 1H), 2.1-2.02 (m, 4H), 0.95 (t, 6H), 0.81 (t, 6H); MS (ES+): m/z 533.2 (M+1).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08722901B2 |
| 出典データセット | uspto-grants-2014_05 |
| ORD ID | ord-ef37235f957042b9a0ea56d138298beb |
| 出典メモ | uspto-grants-2014_05 |