5-Bromopentanenitrile → HCID 66818240、化合物
反応式
[C:1]([O:5][C:6](=[O:33])[NH:7][CH:8]1[CH2:13][CH2:12][CH:11]([NH:14][C:15](=[O:32])[C:16]2[CH:21]=[C:20]([OH:22])[CH:19]=[C:18]([O:23][C:24]3[CH:29]=[CH:28][C:27]([C:30]#[N:31])=[CH:26][CH:25]=3)[CH:17]=2)[CH2:10][CH2:9]1)([CH3:4])([CH3:3])[CH3:2].Br[CH2:35][CH2:36][CH2:37][CH2:38][C:39]#[N:40]>>[C:1]([O:5][C:6](=[O:33])[NH:7][CH:8]1[CH2:13][CH2:12][CH:11]([NH:14][C:15](=[O:32])[C:16]2[CH:17]=[C:18]([O:23][C:24]3[CH:29]=[CH:28][C:27]([C:30]#[N:31])=[CH:26][CH:25]=3)[CH:19]=[C:20]([O:22][CH2:35][CH2:36][CH2:37][CH2:38][C:39]#[N:40])[CH:21]=2)[CH2:10][CH2:9]1)([CH3:4])([CH3:2])[CH3:3]参加物
3
実験手順
Using 0.85 g (1.88 mmol) of {4-[3-(4-cyanophenoxy)-5-hydroxybenzoylamino]cyclohexyl}carbamic acid tert-butyl ester and 5-bromo-pentanenitrile (0.304 g, 1.88 mmol) and following the procedure of Example 42(b) afforded 1.0 g of the required product. 1H NMR (DMSO-d6): δ 1.25 (3H, m), 1.4 (9H, s), 18 (7H, m), 2.6 (3H, m), 3.2 (1H, m), 3.7 (1H, m), 4.2 (2H, m), 6.76 (1H, d), 6.92 (1H, s), 7.14 (3H, m), 7.34 (1H, s), 7.88 (2H, d), 8.28 (1H, d).
出典と根拠
- ORDレコード
- ord-38a9fc11f8b84653bd552ca1d2c9771d
- 出典データセット
- uspto-grants-2014_05