Ethanol → 5-(Ethoxymethyl)picolinonitrile
反応式
CS([O:5][CH2:6][C:7]1[CH:8]=[N:9][C:10]([C:13]#[N:14])=[CH:11][CH:12]=1)(=O)=O.[CH3:15][CH2:16]O>>[CH2:15]([O:5][CH2:6][C:7]1[CH:12]=[CH:11][C:10]([C:13]#[N:14])=[N:9][CH:8]=1)[CH3:16]参加物
3
実験手順
(6-Cyanopyridin-3-yl)methyl methanesulfonate (199 mg, 0.94 mmol) in 2 mL anhydrous EtOH was heated at 85° C. in a sealed tube for 3.5 h. The mixture was concentrated and purified by silica gel chromatography (elution with 0-25% EtOAc/Hex) to afford 5-(ethoxymethyl)picolinonitrile (104 mg).
後処理
- concentrationThe mixture was concentrated
- custompurified by silica gel chromatography (elution with 0-25% EtOAc/Hex)
出典と根拠
- ORDレコード
- ord-0f2b3ec2ac424c3a9666747ef33c3896
- 出典データセット
- uspto-grants-2014_05
- 特許番号
- US08729071B2
反応ノート
読み込み中…