Hydrochloric Acid → (2S,3S)-3-amino-N-cyclopropyl-2-hydroxypentanamide dihydrochloride

HRID 1025293

反応式

HRID 1025293 の反応式
[CH:1]1([NH:4][C:5](=[O:19])[C@@H:6]([OH:18])[C@@H:7]([NH:10]C(=O)OC(C)(C)C)[CH2:8][CH3:9])[CH2:3][CH2:2]1.[ClH:20]>O1CCOCC1>[ClH:20].[ClH:20].[NH2:10][C@@H:7]([CH2:8][CH3:9])[C@H:6]([OH:18])[C:5]([NH:4][CH:1]1[CH2:2][CH2:3]1)=[O:19]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 86762402tert-butyl (2S,3S)-1-(cyclopropylamino)-2-hydroxy-1-oxopentan-3-ylcarbamate

生成物 1

HCID 86762404(2S,3S)-3-amino-N-cyclopropyl-2-hydroxypentanamide dihydrochloride

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

Under an atmosphere of argon, tert-butyl (2S,3S)-1-(cyclopropylamino)-2-hydroxy-1-oxopentan-3-ylcarbamate (540 mg, 1.98 mmol) and HCl 4N in dioxane (10.4 ml) were combined to give a light brown solution. The reaction was stirred for 4 h at RT. The solvent was evaporated. The residual solvent was removed under vacuum. The title compound was obtained as a brown solid (480 mg, quant., MS (m/e)=173.2 [M+H+].

後処理

  1. customto give a light brown solution
  2. customThe solvent was evaporated
  3. customThe residual solvent was removed under vacuum

出典と根拠

ORDレコード
ord-e5fea5f5dde2408fbb40d99a5bfb0f8a
出典データセット
uspto-grants-2014_05
特許番号
US08729061B2

関連ノート

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