(1-Formylcyclopropyl)carbamic acid tert-butyl ester → 2-(1-aminocyclopropyl)-N-cyclopropyl-2-hydroxyacetamide

HRID 1025303

反応式

HRID 1025303 の反応式
Cl.Cl.[NH2:3][C@@H:4]([CH2:13][CH3:14])[C@H:5]([OH:12])[C:6]([NH:8][CH:9]1[CH2:11][CH2:10]1)=[O:7].C(C1(NC(=O)OC(C)(C)C)CC1)=O>>[NH2:3][C:4]1([CH:5]([OH:12])[C:6]([NH:8][CH:9]2[CH2:10][CH2:11]2)=[O:7])[CH2:14][CH2:13]1

参加物

3

反応物 2

HCID 10352385(1-Formylcyclopropyl)carbamic acid tert-butyl esterHCID 86762404(2S,3S)-3-amino-N-cyclopropyl-2-hydroxypentanamide dihydrochloride

生成物 1

HCID 575620962-(1-aminocyclopropyl)-N-cyclopropyl-2-hydroxyacetamide

実験手順

The title compound was prepared in analogy to (2S,3S)-3-amino-N-cyclopropyl-2-hydroxypentanamide dihydrochloride, Representative Procedure A, starting with tert-butyl 1-formylcyclopropylcarbamate in the third step (A3).

出典と根拠

ORDレコード
ord-7cab54402649426cb55b94ad5a505f70
出典データセット
uspto-grants-2014_05
特許番号
US08729061B2

関連ノート

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