2-Chloro-5-propylpyrimidine → 2-(4-(5-Bromo-7-fluoro-2,3-dihydrobenzofuran-2-yl)piperidin-1-yl)-5-propylpyrimidine
反応式
BrC1C=C(F)C2OC(C3CCNCC3)CC=2C=1.ClC1N=CC(CCC)=CN=1.[Br:28][C:29]1[CH:30]=[C:31]([F:54])[C:32]2[O:36][CH:35]([C:37]3(O)[CH2:42][CH2:41][N:40]([C:43]4[N:48]=[CH:47][C:46]([CH2:49][CH2:50][CH3:51])=[CH:45][N:44]=4)[CH2:39][CH2:38]3)[CH2:34][C:33]=2[CH:53]=1>>[Br:28][C:29]1[CH:30]=[C:31]([F:54])[C:32]2[O:36][CH:35]([CH:37]3[CH2:38][CH2:39][N:40]([C:43]4[N:44]=[CH:45][C:46]([CH2:49][CH2:50][CH3:51])=[CH:47][N:48]=4)[CH2:41][CH2:42]3)[CH2:34][C:33]=2[CH:53]=1参加物
4
反応物 3
生成物 1
実験手順
Compound 3F was prepared from Compound 3E and 2-chloro-5-propylpyrimidine in a similar manner to the procedure described in Compound 1H, Example 1. LC/MS (m/z)=421 (M+H)+.