Acetic Anhydride → 2-acetamido-6-(4-fluorophenyl)-pyrido[3,2-d]pyrimidin-4(3H)-one

HRID 1025517ノート

反応式

HRID 1025517 の反応式
[NH2:1][C:2]1[NH:3][C:4](=[O:19])[C:5]2[N:11]=[C:10]([C:12]3[CH:17]=[CH:16][C:15]([F:18])=[CH:14][CH:13]=3)[CH:9]=[CH:8][C:6]=2[N:7]=1.[C:20](OC(=O)C)(=[O:22])[CH3:21]>C(O)(=O)C>[C:20]([NH:1][C:2]1[NH:3][C:4](=[O:19])[C:5]2[N:11]=[C:10]([C:12]3[CH:17]=[CH:16][C:15]([F:18])=[CH:14][CH:13]=3)[CH:9]=[CH:8][C:6]=2[N:7]=1)(=[O:22])[CH3:21]

参加物

4

反応物 2

HCID 7918Acetic AnhydrideHCID 1361375922-Amino-6-(4-fluorophenyl)pyrido[3,2-d]pyrimidin-4(1H)-one

生成物 1

HCID 1360008912-acetamido-6-(4-fluorophenyl)-pyrido[3,2-d]pyrimidin-4(3H)-one収率 78%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

A suspension of 2-amino-6-(4-fluorophenyl)-pyrido[3,2-d]pyrimidin-4(3H)-one (2.0 g) in acetic anhydride (180 ml) and acetic acid (20 ml) was refluxed for 16 hours. The hot suspension was filtered and the filtrate was concentrated under reduced pressure until crystallization started. The precipitate was filtered off to give the pure title compound in 78% yield. The compound was characterized by its mass spectrum as follows: MS (m/z): 299 ([M+H]+, 100).

後処理

  1. temperaturewas refluxed for 16 hours
  2. filtrationThe hot suspension was filtered
  3. concentrationthe filtrate was concentrated under reduced pressure until crystallization
  4. filtrationThe precipitate was filtered off

出典と根拠

ORDレコード
ord-7638cfebe31e4703a5e4cd0c223121e1
出典データセット
uspto-grants-2014_05
特許番号
US08729089B2

反応ノート

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