2-acetamido-4-(N-isopropylamino)-6-(4-fluorophenyl)-pyrido[3,2-d]pyrimidine → 2-amino-4-(N-isopropylamino)-6-(4-fluorophenyl)pyrido-[3,2-d]pyrimidine

HRID 1025520ノート

反応式

HRID 1025520 の反応式
C([NH:4][C:5]1[N:6]=[C:7]([NH:22][CH:23]([CH3:25])[CH3:24])[C:8]2[N:14]=[C:13]([C:15]3[CH:20]=[CH:19][C:18]([F:21])=[CH:17][CH:16]=3)[CH:12]=[CH:11][C:9]=2[N:10]=1)(=O)C>ClCCl.[O-]CC.[Na+]>[NH2:4][C:5]1[N:6]=[C:7]([NH:22][CH:23]([CH3:25])[CH3:24])[C:8]2[N:14]=[C:13]([C:15]3[CH:20]=[CH:19][C:18]([F:21])=[CH:17][CH:16]=3)[CH:12]=[CH:11][C:9]=2[N:10]=1

参加物

4

反応物 1

HCID 690791042-acetamido-4-(N-isopropylamino)-6-(4-fluorophenyl)-pyrido[3,2-d]pyrimidine

生成物 1

HCID 690788992-amino-4-(N-isopropylamino)-6-(4-fluorophenyl)pyrido-[3,2-d]pyrimidine収率 61%

試薬・触媒・溶媒 2

HCID 6344Dichloromethane溶媒HCID 2723922Sodium ethoxide溶媒

実験手順

The crude 2-acetamido-4-(N-isopropylamino)-6-(4-fluorophenyl)pyrido[3,2-d]pyrimidine of example 3 (0.5 mmol) was suspended in a mixture of dichloromethane (10 ml) and 0.5 N sodium ethoxide (10 ml). The reaction mixture was stirred for 16 hours at room temperature. The solvents were evaporated in vacuo and the crude residue was purified by preparative thin layer chromatography on silica, using a mixture of methanol and dichloromethane (in a volume ratio of 10:90) as a mobile phase providing, in a yield of 61%, the pure title compound which was characterized by its mass spectra as follows: MS (m/z): 298 ([M+H]+, 100).

後処理

  1. customThe solvents were evaporated in vacuo
  2. customthe crude residue was purified by preparative thin layer chromatography on silica
  3. additiona mixture of methanol and dichloromethane (in a volume ratio of 10:90) as a mobile phase
  4. customproviding, in a yield of 61%

出典と根拠

ORDレコード
ord-40a2ec3b4a874195beecdd7ae42d7a90
出典データセット
uspto-grants-2014_05
特許番号
US08729089B2

反応ノート

読み込み中…