Potassium Carbonate → N-(4-bromophenyl)-2-(4-ethyl-4-isopropyl-2,5-dioxoimidazolidin-1-yl)acetamide

HRID 1025533ノート

反応式

HRID 1025533 の反応式
[CH2:1]([C:3]1([CH:10]([CH3:12])[CH3:11])[NH:7][C:6](=[O:8])[NH:5][C:4]1=[O:9])[CH3:2].[Br:13][C:14]1[CH:19]=[CH:18][C:17]([NH:20][C:21](=[O:24])[CH2:22]Cl)=[CH:16][CH:15]=1.C([O-])([O-])=O.[K+].[K+]>CC(C)=O>[Br:13][C:14]1[CH:15]=[CH:16][C:17]([NH:20][C:21](=[O:24])[CH2:22][N:5]2[C:4](=[O:9])[C:3]([CH2:1][CH3:2])([CH:10]([CH3:11])[CH3:12])[NH:7][C:6]2=[O:8])=[CH:18][CH:19]=1

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 17374N-(4-Bromophenyl)-2-chloroacetamideHCID 2345135-Ethyl-5-(propan-2-yl)imidazolidine-2,4-dione

生成物 1

HCID 71664632N-(4-bromophenyl)-2-(4-ethyl-4-isopropyl-2,5-dioxoimidazolidin-1-yl)acetamide

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

A mixture of 5-Ethyl-5-(1-methylethyl)-2,4-imidazolidinedione, (CAS #98492-91-2 (50 mg, 0.29 mmol), N-(4-bromophenyl)-2-chloro-acetamide (CAS #2564-02-5) (80 mg, 0.32 mmol), K2CO3 (48 mg, 0.35 mmol) in acetone was stirred at ambient temperature for 18 h. The mixture was extracted with EtOAc, the organic layer was washed with brine, dried over MgSO4, filtered and solvent removed. The crude product was purified by preparative TLC. The title compound was isolated as white solid.

後処理

  1. extractionThe mixture was extracted with EtOAc
  2. washthe organic layer was washed with brine
  3. dry with materialdried over MgSO4
  4. filtrationfiltered
  5. customsolvent removed
  6. customThe crude product was purified by preparative TLC

出典と根拠

ORDレコード
ord-3440bad861ec4af0aaf44df09e30acfb
出典データセット
uspto-grants-2014_05
特許番号
US08729096B2

反応ノート

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