Ammonia → HCID 71008280、化合物

HRID 1025553ノート

反応式

HRID 1025553 の反応式
[NH3:1].C[O:3][C:4]([C:6]1[N:7]([CH3:12])[CH:8]=[C:9]([Br:11])[N:10]=1)=O>CO>[Br:11][C:9]1[N:10]=[C:6]([C:4]([NH2:1])=[O:3])[N:7]([CH3:12])[CH:8]=1

参加物

4

反応物 2

HCID 222AmmoniaHCID 53302209methyl 4-bromo-1-methyl-1H-imidazole-2-carboxylate

生成物 1

HCID 71008280HCID 71008280、化合物収率 100%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

反応条件

温度
20 °C

実験手順

To the saturated solution of ammonia in MeOH was added 165 mg of 4-bromo-1-methyl-1H-imidazole-2-carboxylic acid methyl ester and the resulting mixture was stirred at 20° C. for 16 h. The solution was evaporated to give 4-bromo-1-methyl-1H-imidazole-2-carboxylic acid amide (154 mg, yield 100%). LC-MS calcd for C5H6BrN3O (m/e) 202.97, obsd 204 and 206 [M+1]+.

後処理

  1. customThe solution was evaporated

出典と根拠

ORDレコード
ord-4d9f8370063647669c10e393382f8540
出典データセット
uspto-grants-2014_05
特許番号
US08729078B2

反応ノート

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