Water → (2-Bromo-4-hydroxyphenyl)acetic acid

HRID 1026350ノート

反応式

HRID 1026350 の反応式
[Br:1][C:2]1[CH:7]=[C:6]([O:8]C)[CH:5]=[CH:4][C:3]=1[CH2:10][C:11]([OH:13])=[O:12].BrB(Br)Br.O>ClCCl>[Br:1][C:2]1[CH:7]=[C:6]([OH:8])[CH:5]=[CH:4][C:3]=1[CH2:10][C:11]([OH:13])=[O:12]

参加物

5

反応物 3

HCID 962WaterHCID 25134Boron tribromideHCID 39636682-Bromo-4-methoxyphenylacetic acid

生成物 1

HCID 24721648(2-Bromo-4-hydroxyphenyl)acetic acid収率 97.4%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a solution of (2-bromo-4-methoxyphenyl)acetic acid (0.49 g) in dichloromethane (5 mL) was added a solution of tribromoborane (5 mL) dropwise at room temperature. The mixture was refluxed for 3 hr. After cooling to room temperature, the mixture was poured into iced water. The organic layer was separated, and the water layer was extracted by ethyl acetate (30 mL×3). The combined organic layer was dried over anhydrous sodium sulfate, filtered and evaporated to dryness. The residue was washed with ether to give the title compound (0.45 g).

後処理

  1. temperatureThe mixture was refluxed for 3 hr
  2. customThe organic layer was separated
  3. extractionthe water layer was extracted by ethyl acetate (30 mL×3)
  4. dry with materialThe combined organic layer was dried over anhydrous sodium sulfate
  5. filtrationfiltered
  6. customevaporated to dryness
  7. washThe residue was washed with ether

出典と根拠

ORDレコード
ord-7ca949c592364508b5e8353ff6acfa05
出典データセット
uspto-grants-2014_05
特許番号
US08729102B2

反応ノート

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