tert-butyl 4-{[(2R)-2-(benzyloxy)propanoyl]amino}piperidine-1-carboxylate → tert-butyl 4-{[(2R)-2-hydroxypropanoyl]amino}piperidine-1-carboxylate

HRID 1026542ノート

反応式

HRID 1026542 の反応式
C([O:8][C@H:9]([CH3:26])[C:10]([NH:12][CH:13]1[CH2:18][CH2:17][N:16]([C:19]([O:21][C:22]([CH3:25])([CH3:24])[CH3:23])=[O:20])[CH2:15][CH2:14]1)=[O:11])C1C=CC=CC=1>[C].[Pd].CO>[OH:8][C@H:9]([CH3:26])[C:10]([NH:12][CH:13]1[CH2:18][CH2:17][N:16]([C:19]([O:21][C:22]([CH3:25])([CH3:24])[CH3:23])=[O:20])[CH2:15][CH2:14]1)=[O:11]

参加物

4

反応物 1

HCID 52331793tert-butyl 4-{[(2R)-2-(benzyloxy)propanoyl]amino}piperidine-1-carboxylate

生成物 1

HCID 68500407tert-butyl 4-{[(2R)-2-hydroxypropanoyl]amino}piperidine-1-carboxylate収率 100.1%

試薬・触媒・溶媒 2

HCID 178418390HCID 178418390、化合物触媒HCID 887Methanol溶媒

実験手順

At room temperature, to a methanol solution (200 ml) of tert-butyl 4-{[(2R)-2-(benzyloxy)propanoyl]amino}piperidine-1-carboxylate (6.90 g) was added 10% palladium carbon (2.03 g), followed by stirring overnight under a hydrogen atmosphere. The reaction solution was filtered through Celite, and then concentrated under reduced pressure to afford tert-butyl 4-{[(2R)-2-hydroxypropanoyl]amino}piperidine-1-carboxylate (5.19 g).

後処理

  1. filtrationThe reaction solution was filtered through Celite
  2. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-6504e2b6ee51466a8d70bdf03f882fda
出典データセット
uspto-grants-2014_05
特許番号
US08729095B2

反応ノート

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