化工社化工社 化学情報印刷レポート · 研究参考用
Benzylsulfamic acid [5-(2-chloro-5-methoxy-phenoxy)-6-(2-hydroxy-ethoxy) pyrimidin-4-yl]-amide → Benzylsulfamic acid [6-[2-(5-methylsulfanyl-pyrimidin-2-yloxy)ethoxy]-5-(2-chloro-5-methoxy-phenoxy)pyrimidin-4-yl]-amide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Benzylsulfamic acid [5-(2-chloro-5-methoxy-phenoxy)-6-(2-hydroxy-ethoxy) pyrimidin-4-yl]-amide | HCID 21041229 | — |
| 反応物 | 2-Chloro-5-(methylthio)pyrimidine | HCID 21979532 | — |
| 生成物 | Benzylsulfamic acid [6-[2-(5-methylsulfanyl-pyrimidin-2-yloxy)ethoxy]-5-(2-chloro-5-methoxy-phenoxy)pyrimidin-4-yl]-amide | HCID 21979560 | 45.7% |
反応手順
Benzylsulfamic acid [6-[2-(5-methylsulfanyl-pyrimidin-2-yloxy)-ethoxy]-5-(2-chloro-5-methoxy-phenoxy)-pyrimidin-4-yl]-amide (138 mg) (Example 213) was prepared from benzylsulfamic acid [5-(2-chloro-5-methoxy-phenoxy)-6-(2-hydroxy-ethoxy)-pyrimidin-4-yl]-amide (240 mg) (Example 211) and 5-methylsulfanyl-2-chloropyrimidine (180 mg) according to the procedure described in Example 14. LC-MS: tR=5.22; [M+H]+=606.75.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07094781B2 |
| 出典データセット | uspto-grants-2006_08 |
| ORD ID | ord-0557e87742a0462f9f27941c55dcda0f |
| 出典メモ | uspto-grants-2006_08 |