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2-Fluoro-3-methylaniline → 3-Ethoxycarbonyl-7-(2-fluoro-3-methylphenylamino)-6-(4-phenylpiperidine-1-carbonyl)pyrazolo[1,5-a]pyrimidine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Fluoro-3-methylaniline | HCID 22734623 | — |
| 反応物 | 7-Chloro-3-ethoxycarbonyl-6-(4-phenylpiperidine-1-carbonyl)pyrazolo[1,5-a]pyrimidine | HCID 86646290 | — |
| 生成物 | 3-Ethoxycarbonyl-7-(2-fluoro-3-methylphenylamino)-6-(4-phenylpiperidine-1-carbonyl)pyrazolo[1,5-a]pyrimidine | HCID 67539869 | 99.7% |
反応手順
In the same manner as in Example 19, step 5 and using 7-chloro-3-ethoxycarbonyl-6-(4-phenylpiperidine-1-carbonyl)pyrazolo[1,5-a]pyrimidine (100 mg, 0.24 mmol) obtained in Example 19, step 4 and 2-fluoro-3-methylaniline (46 mg, 0.36 mmol), the title compound (120 mg, 99%) was obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08729264B2 |
| 出典データセット | uspto-grants-2014_05 |
| ORD ID | ord-3087c2c910614341a6e4b06295b60ebb |
| 出典メモ | uspto-grants-2014_05 |