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3-Amino-2-methylpyridine → 3-Ethoxycarbonyl-7-(2-methyl-3-pyridylamino)-6-(4-phenylpiperidine-1-carbonyl)pyrazolo[1,5-a]pyrimidine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-Amino-2-methylpyridine | HCID 572616 | — |
| 反応物 | 7-Chloro-3-ethoxycarbonyl-6-(4-phenylpiperidine-1-carbonyl)pyrazolo[1,5-a]pyrimidine | HCID 86646290 | — |
| 生成物 | 3-Ethoxycarbonyl-7-(2-methyl-3-pyridylamino)-6-(4-phenylpiperidine-1-carbonyl)pyrazolo[1,5-a]pyrimidine | HCID 67540430 | 64.5% |
反応手順
In the same manner as in Example 19, step 5 and using 7-chloro-3-ethoxycarbonyl-6-(4-phenylpiperidine-1-carbonyl)pyrazolo[1,5-a]pyrimidine (0.20 g, 0.48 mmol) obtained in Example 19, step 4 and 3-amino-2-methylpyridine (0.105 g, 0.97 mmol), the title compound (0.150 g, 64%) was obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08729264B2 |
| 出典データセット | uspto-grants-2014_05 |
| ORD ID | ord-4259d052b1794dda83d09adbbe29265f |
| 出典メモ | uspto-grants-2014_05 |