4-(3,4-Difluorophenyl)piperidine hydrochloride → 6-[4-(3,4-Difluorophenyl)piperidine-1-carbonyl]-3-ethoxycarbonyl-7-(2-fluoro-5-methylphenylamino)pyrazolo[1,5-a]pyrimidine
反応式
[CH2:1]([O:3][C:4]([C:6]1[CH:7]=[N:8][N:9]2[C:14]([NH:15][C:16]3[CH:21]=[C:20]([CH3:22])[CH:19]=[CH:18][C:17]=3[F:23])=[C:13]([C:24](O)=[O:25])[CH:12]=[N:11][C:10]=12)=[O:5])[CH3:2].Cl.[F:28][C:29]1[CH:30]=[C:31]([CH:36]2[CH2:41][CH2:40][NH:39][CH2:38][CH2:37]2)[CH:32]=[CH:33][C:34]=1[F:35]>>[F:28][C:29]1[CH:30]=[C:31]([CH:36]2[CH2:41][CH2:40][N:39]([C:24]([C:13]3[CH:12]=[N:11][C:10]4[N:9]([N:8]=[CH:7][C:6]=4[C:4]([O:3][CH2:1][CH3:2])=[O:5])[C:14]=3[NH:15][C:16]3[CH:21]=[C:20]([CH3:22])[CH:19]=[CH:18][C:17]=3[F:23])=[O:25])[CH2:38][CH2:37]2)[CH:32]=[CH:33][C:34]=1[F:35]参加物
3
反応物 2
生成物 1
実験手順
In the same manner as in Example 21, step 5 and using 3-ethoxycarbonyl-7-(2-fluoro-5-methylphenylamino)pyrazolo[1,5-a]pyrimidine-6-carboxylic acid (150 mg, 0.42 mmol) obtained in step 2 and 4-(3,4-difluorophenyl)piperidine hydrochloride (WO2004/069798, 127 mg, 0.55 mmol), the title compound (63 mg, 28%) was obtained.
出典と根拠
- ORDレコード
- ord-7d64eb0cf858451da8b7e85086ea1377
- 出典データセット
- uspto-grants-2014_05
- 特許番号
- US08729264B2
反応ノート
読み込み中…