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4-(4-Fluorophenyl)-1,2,3,6-tetrahydropyridine hydrochloride → 7-(2,5-Dimethylphenylamino)-3-ethoxycarbonyl-6-[4-(4-fluorophenyl)-1,2,3,6-tetrahydropyridine-1-carbonyl]pyrazolo[1,5-a]pyrimidine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-(4-Fluorophenyl)-1,2,3,6-tetrahydropyridine hydrochloride | HCID 197747 | — |
| 反応物 | 7-(2,5-Dimethylphenylamino)-3-ethoxycarbonylpyrazolo[1,5-a]pyrimidine-6-carboxylic acid | HCID 67540739 | — |
| 生成物 | 7-(2,5-Dimethylphenylamino)-3-ethoxycarbonyl-6-[4-(4-fluorophenyl)-1,2,3,6-tetrahydropyridine-1-carbonyl]pyrazolo[1,5-a]pyrimidine | HCID 67540807 | 75% |
反応手順
In the same manner as in Example 21, step 5 and using 7-(2,5-dimethylphenylamino)-3-ethoxycarbonylpyrazolo[1,5-a]pyrimidine-6-carboxylic acid (110 mg, 0.31 mmol) obtained in Example 88, step 2 and 4-(4-fluorophenyl)-1,2,3,6-tetrahydropyridine hydrochloride (79 mg, 0.37 mmol), the title compound (119 mg, 75%) was obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08729264B2 |
| 出典データセット | uspto-grants-2014_05 |
| ORD ID | ord-d6689159ee5d41b1ab7063f0db2d40dd |
| 出典メモ | uspto-grants-2014_05 |