tert-Butyl spiro(indole-3,4'-piperidine)-1(2H)-carboxylate → 7-Benzylamino-6-(1-(tert-butoxycarbonyl)spiro[indoline-3,4'-piperidine]-1'-ylcarbonyl)-3-ethoxycarbonylpyrazolo[1,5-a]pyrimidine

HRID 1027127ノート

反応式

HRID 1027127 の反応式
[CH2:1]([NH:8][C:9]1[N:14]2[N:15]=[CH:16][C:17]([C:18]([O:20][CH2:21][CH3:22])=[O:19])=[C:13]2[N:12]=[CH:11][C:10]=1[C:23](O)=[O:24])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH:26]1[CH2:31][CH2:30][C:29]2([C:39]3[C:34](=[CH:35][CH:36]=[CH:37][CH:38]=3)[N:33]([C:40]([O:42][C:43]([CH3:46])([CH3:45])[CH3:44])=[O:41])[CH2:32]2)[CH2:28][CH2:27]1>>[CH2:1]([NH:8][C:9]1[N:14]2[N:15]=[CH:16][C:17]([C:18]([O:20][CH2:21][CH3:22])=[O:19])=[C:13]2[N:12]=[CH:11][C:10]=1[C:23]([N:26]1[CH2:27][CH2:28][C:29]2([C:39]3[C:34](=[CH:35][CH:36]=[CH:37][CH:38]=3)[N:33]([C:40]([O:42][C:43]([CH3:46])([CH3:45])[CH3:44])=[O:41])[CH2:32]2)[CH2:30][CH2:31]1)=[O:24])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

3

反応物 2

HCID 23572861tert-Butyl spiro(indole-3,4'-piperidine)-1(2H)-carboxylateHCID 675407947-Benzylamino-3-ethoxycarbonylpyrazolo[1,5-a]pyrimidine-6-carboxylic acid

生成物 1

HCID 675408247-Benzylamino-6-(1-(tert-butoxycarbonyl)spiro[indoline-3,4'-piperidine]-1'-ylcarbonyl)-3-ethoxycarbonylpyrazolo[1,5-a]pyrimidine収率 79.3%

実験手順

In the same manner as in Example 21, step 5 and using 7-benzylamino-3-ethoxycarbonylpyrazolo[1,5-a]pyrimidine-6-carboxylic acid (0.363 g, 1.07 mmol) obtained in Example 21, step 4 and tert-butyl spiro[indoline-3,4′-piperidine]-1-carboxylate (0.370 g, 1.28 mmmol) obtained in Reference Example 8, the title compound (0.518 g, 79%) was obtained.

後処理

  1. customobtained in Reference Example 8

出典と根拠

ORDレコード
ord-0391bfd0e71f41e083001f258de22ecd
出典データセット
uspto-grants-2014_05
特許番号
US08729264B2

反応ノート

読み込み中…