Ammonia → 2'-Deoxy-2'-fluoro-2'-methyluridine
反応式
C([C@@:9]1([OH:34])[C@@H:13]([CH:14](C(=O)C2C=CC=CC=2)[OH:15])[O:12][C@@H:11]([N:24]2[CH:31]=[CH:30][C:28](=[O:29])[NH:27][C:25]2=[O:26])[C@@:10]1([F:33])[CH3:32])(=O)C1C=CC=CC=1.N>CO>[F:33][C@:10]1([CH3:32])[C@H:9]([OH:34])[C@@H:13]([CH2:14][OH:15])[O:12][C@H:11]1[N:24]1[CH:31]=[CH:30][C:28](=[O:29])[NH:27][C:25]1=[O:26]参加物
4
反応条件
- 温度
- 0 °C
実験手順
To a solution of 3′,5′-dibenzoyl-2′-Deoxy-2′-fluoro-2′-C-methyluridine (1.5 g, 1 eq) in MeOH (10 mL) was added a solution of saturated ammonia in MeOH (20 mL). The reaction mixture was stirred at 0° C. for 30 min, and then warmed to room temperature slowly. After the reaction mixture was stirred for another 18 hours, the reaction mixture was evaporated under reduced pressure to give the residue, which was purified by column chromatography to afford pure compound 2′-deoxy-2′-fluoro-2′-C-methyluridine (500 mg, Yield: 60%).