Sodium methanesulfinate → Benzyl 3-[4-(5-methanesulfonyloxazolo[5,4-d]pyrimidin-2-yl)-2,6-dimethylphenoxy]cyclobutanecarboxylate
反応式
Cl[C:2]1[N:3]=[CH:4][C:5]2[N:10]=[C:9]([C:11]3[CH:31]=[C:30]([CH3:32])[C:14]([O:15][CH:16]4[CH2:19][CH:18]([C:20]([O:22][CH2:23][C:24]5[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=5)=[O:21])[CH2:17]4)=[C:13]([CH3:33])[CH:12]=3)[O:8][C:6]=2[N:7]=1.[CH3:34][S:35]([O-:37])=[O:36].[Na+]>CN(C)C=O>[CH3:34][S:35]([C:2]1[N:3]=[CH:4][C:5]2[N:10]=[C:9]([C:11]3[CH:31]=[C:30]([CH3:32])[C:14]([O:15][CH:16]4[CH2:19][CH:18]([C:20]([O:22][CH2:23][C:24]5[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=5)=[O:21])[CH2:17]4)=[C:13]([CH3:33])[CH:12]=3)[O:8][C:6]=2[N:7]=1)(=[O:37])=[O:36]参加物
4
反応物 2
生成物 1
試薬・触媒・溶媒 1
実験手順
A solution of 200 mg of benzyl 3-[4-(5-chlorooxazolo[5,4-d]pyrimidin-2-yl)-2,6-dimethylphenoxy]cyclobutanecarboxylate and 48 mg of sodium methylsulfinate in 4 ml of N,N-dimethylformamide was heated in a microwave reactor at 100° C. for 60 min. At room temperature, the mixture was filtered and then washed with DMF. The filtrate was concentrated and the resulting residue was purified by preparative HPLC. This gave 71 mg (32%) of the title compound.