Chlorosulfonyl isocyanate → 6-Bromo-5-fluoro-1H-indole-3-carbonitrile
反応式
[Br:1][C:2]1[CH:10]=[C:9]2[C:5]([CH:6]=[CH:7][NH:8]2)=[CH:4][C:3]=1[F:11].ClS([N:16]=[C:17]=O)(=O)=O>CN(C=O)C>[Br:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([C:17]#[N:16])=[CH:7][NH:8]2)=[CH:4][C:3]=1[F:11]参加物
4
実験手順
To 6-bromo-5-fluoro-1H-indole (9.4 g, 43.9 mmol) in DMF (50 mL) at −78° C. was added chlorosulfonyl isocyanate (4.6 mL, 53 mmol). After complete addition the mixture was allowed to warm to room temperature and stir for 2 hrs. The reaction mixture was poured into ice water and stirred for 30 minutes. The precipitate was collected on a filter, washed with ice water and dried in a vacuum oven to give 6-bromo-5-fluoro-1H-indole-3-carbonitrile as a light-beige solid (10.5 g, 100%).
後処理
- additionAfter complete addition the mixture
- stirringstirred for 30 minutes
- customThe precipitate was collected on a filter
- washwashed with ice water
- customdried in a vacuum oven
出典と根拠
- ORDレコード
- ord-e3d4899e65b14de1911901fe2ae5dafc
- 出典データセット
- uspto-grants-2014_05
- 特許番号
- US08735414B2
反応ノート
読み込み中…