Hydrochloric Acid → Methyl 2-(4-oxocyclohexyl)acetate

HRID 1028200ノート

反応式

HRID 1028200 の反応式
Cl.[CH3:2][O:3][C:4](=[O:16])[CH2:5][CH:6]1[CH2:15][CH2:14][C:9]2(OCC[O:10]2)[CH2:8][CH2:7]1>CC(C)=O>[CH3:2][O:3][C:4](=[O:16])[CH2:5][CH:6]1[CH2:15][CH2:14][C:9](=[O:10])[CH2:8][CH2:7]1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 20711792Methyl 2-(1,4-dioxaspiro[4.5]decan-8-yl)acetate

生成物 1

HCID 21249113Methyl 2-(4-oxocyclohexyl)acetate収率 108.5%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

A 1 N aqueous hydrochloric acid solution (50 mL)/acetone (200 ml) mixture of (1,4-dioxa-spiro[4.5]dec-8-yl)-acetic acid methyl ester (4.99 g) obtained in Example (1b) was stirred at room temperature for 15 hours. The organic solvent was removed using an evaporator. The remaining aqueous solution was subjected to two extractions with ethyl acetate. The organic layer was washed with saturated brine, then dried over sodium sulfate, and then concentrated to obtain the title compound (4.30 g, quantitative yield) as a colorless oil.

後処理

  1. customThe organic solvent was removed
  2. customan evaporator
  3. extractionThe remaining aqueous solution was subjected to two extractions with ethyl acetate
  4. washThe organic layer was washed with saturated brine
  5. dry with materialdried over sodium sulfate
  6. concentrationconcentrated

出典と根拠

ORDレコード
ord-fb35a696927b494fbeb28c853f0474a5
出典データセット
uspto-grants-2014_05
特許番号
US08735425B2

反応ノート

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