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Bromine → 6-Amino-5-bromopyridine-3-carbonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Bromine | HCID 24408 | — |
| 反応物 | 2-Amino-5-cyanopyridine | HCID 818260 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 生成物 | 6-Amino-5-bromopyridine-3-carbonitrile | HCID 1491250 | 49.5% |
反応手順
Br2 (0.52 mL, 0.01 mol) was added to a solution of 6-aminonicotinonitrile (1.1901 g, 0.01 mol) in AcOH (10 mL) at room temperature. The mixture was stirred at room temperature for 2 h. Then the mixture was concentrated and the residue was purified by flash column chromatography to give the title product (980.0 mg, 49%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08735440B2 |
| 出典データセット | uspto-grants-2014_05 |
| ORD ID | ord-1f7dffa32c274d558d4b0459e33724d8 |
| 出典メモ | uspto-grants-2014_05 |