化工社化工社 化学情報印刷レポート · 研究参考用
2-Oxobutanoic Acid → ethyl acetoacetate, sodium salt
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Oxobutanoic Acid | HCID 58 | — |
| 反応物 | p-Toluenesulfonic acid monohydrate | HCID 521998 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | ethyl acetoacetate, sodium salt | HCID 85195 | 16,662.4% |
反応手順
2-Oxo-butyric acid (10.0 g, 97.2 mmol) was dissolved in ethanol (100 mL) and p-toluene sulfonic acid mono hydrate (0.1 g) was added. The reaction mixture was heated to reflux for 48 h. After cooling the reaction mixture to room temperature, the ethanol was removed under reduced pressure to give 11.4 g of 2-oxo-butyric acid ethyl ester.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08735588B2 |
| 出典データセット | uspto-grants-2014_05 |
| ORD ID | ord-1067fd82c6ef4ddeb78934f25c0d7c54 |
| 出典メモ | uspto-grants-2014_05 |