化工社化工社 化学情報印刷レポート · 研究参考用
Bromine → Ethyl 3-bromo-2-oxobutanoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Bromine | HCID 24408 | — |
| 反応物 | ethyl acetoacetate, sodium salt | HCID 85195 | — |
| 溶媒 | Chloroform | HCID 6212 | — |
| 生成物 | Ethyl 3-bromo-2-oxobutanoate | HCID 11117285 | — |
反応手順
The 2-oxo-butyric acid ethyl ester prepared above was dissolved in chloroform (100 mL) and bromine (20.964 g, 131.19 mmol) was added dropwise at room temperature. The reaction mixture was allowed to stir for 18 h. Concentration of the reaction mixture under reduced pressure provided 12.0 g of the title compound as an orange oil. 1H NMR (CDCl3) δ 4.39 (q, 2H), 4.32 (q, 1H), 1.88 (d, 3H), 1.39 (t, 3H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08735588B2 |
| 出典データセット | uspto-grants-2014_05 |
| ORD ID | ord-a3102cce8b0343389afa889c1c18dcc1 |
| 出典メモ | uspto-grants-2014_05 |