Water → 6-bromo-3-iodo-N-(4-methoxybenzyl)quinolin-2-amine

HRID 1028989ノート

反応式

HRID 1028989 の反応式
[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7](Cl)[C:6]([I:13])=[CH:5]2.[CH3:14][O:15][C:16]1[CH:23]=[CH:22][C:19]([CH2:20][NH2:21])=[CH:18][CH:17]=1.O>CN1CCCC1=O>[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([NH:21][CH2:20][C:19]1[CH:22]=[CH:23][C:16]([O:15][CH3:14])=[CH:17][CH:18]=1)[C:6]([I:13])=[CH:5]2

参加物

5

反応物 3

HCID 962WaterHCID 754524-MethoxybenzylamineHCID 866768376-Bromo-2-chloro-3-iodoquinoline

生成物 1

HCID 673456526-bromo-3-iodo-N-(4-methoxybenzyl)quinolin-2-amine

試薬・触媒・溶媒 1

HCID 13387N-methyl-2-pyrrolidone溶媒

反応条件

温度
130 °C

実験手順

A glass microwave reaction vessel was charged with 6-bromo-2-chloro-3-iodoquinoline (0.918 g, 2.492 mmol) and 4-methoxybenzylamine (2.279 mL, 17.44 mmol) in N-methyl-2-pyrrolidinone (3.56 mL). The reaction mixture was stirred and heated in a microwave reactor at 130° C. for 20 min. The solution was poured into water and extracted with diethyl ether. The combined organic extracts were washed with saturated ammonium chloride, water, saturated sodium chloride, and dried over magnesium sulfate. The solution was filtered and concentrated in vacuo to give the crude material 6-bromo-3-iodo-N-(4-methoxybenzyl)quinolin-2-amine as a tan solid which was used without further purification.

後処理

  1. customA glass microwave reaction vessel
  2. extractionextracted with diethyl ether
  3. washThe combined organic extracts were washed with saturated ammonium chloride, water, saturated sodium chloride
  4. dry with materialdried over magnesium sulfate
  5. filtrationThe solution was filtered
  6. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-52f3dfeb604f4fb4ad89172184062663
出典データセット
uspto-grants-2014_05
特許番号
US08735384B2

反応ノート

読み込み中…