4-Chloro-3-iodopyridin-2-amine → Methyl 1-chloro-6-oxo-5,6-dihydrobenzo[c][1,8]naphthyridine-8-carboxylate

反応式

[Cl:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([NH2:8])[C:3]=1I.CC1(C)C(C)(C)OB([C:18]2[CH:27]=[CH:26][C:21]([C:22]([O:24][CH3:25])=[O:23])=[CH:20][C:19]=2[C:28](OC)=[O:29])O1>>[Cl:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]2[C:3]=1[C:18]1[CH:27]=[CH:26][C:21]([C:22]([O:24][CH3:25])=[O:23])=[CH:20][C:19]=1[C:28](=[O:29])[NH:8]2

参加物

反応物 2

HCID 229365964-Chloro-3-iodopyridin-2-amine

HCID 68648791Dimethyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isophthalate

生成物 1

HCID 58168369Methyl 1-chloro-6-oxo-5,6-dihydrobenzo[c][1,8]naphthyridine-8-carboxylate収率 48.5%

実験手順

The title compound was synthesized according to the procedure described for the preparation of Example 1 using 4-chloro-3-iodopyridin-2-amine (510 mg, 2.0 mmol) and dimethyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isophthalate (705 mg, 2.2 mmol) to provide 266 (280 mg, 48% yield) as a white solid. LC-MS (M+H=289, obsd.=289).

後処理

customThe title compound was synthesized

出典と根拠

ORDレコード: ord-b33068174aa14663b971489d5dc782fb
出典データセット: uspto-grants-2014_05
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08735584B2

反応ノート

読み込み中…

参加物