N-(4-Aminophenyl)-4-fluoro-2-trifluoromethyl-benzamide → N-(2-(Dimethylamino)ethyl)-1-(4-(4-fluoro-2-(trifluoromethyl)benzamido)phenyl amino)-6-oxo-5,6-dihydrobenzo[c][1,8]naphthyridine-9-carboxamide

HRID 1029238ノート

反応式

HRID 1029238 の反応式
Cl[C:2]1[CH:11]=[CH:10][N:9]=[C:8]2[C:3]=1[C:4]1[CH:16]=[C:15]([C:17]([NH:19][CH2:20][CH2:21][N:22]([CH3:24])[CH3:23])=[O:18])[CH:14]=[CH:13][C:5]=1[C:6](=[O:12])[NH:7]2.[NH2:25][C:26]1[CH:31]=[CH:30][C:29]([NH:32][C:33](=[O:45])[C:34]2[CH:39]=[CH:38][C:37]([F:40])=[CH:36][C:35]=2[C:41]([F:44])([F:43])[F:42])=[CH:28][CH:27]=1>>[CH3:23][N:22]([CH3:24])[CH2:21][CH2:20][NH:19][C:17]([C:15]1[CH:14]=[CH:13][C:5]2[C:6](=[O:12])[NH:7][C:8]3[C:3]([C:4]=2[CH:16]=1)=[C:2]([NH:25][C:26]1[CH:31]=[CH:30][C:29]([NH:32][C:33](=[O:45])[C:34]2[CH:39]=[CH:38][C:37]([F:40])=[CH:36][C:35]=2[C:41]([F:44])([F:42])[F:43])=[CH:28][CH:27]=1)[CH:11]=[CH:10][N:9]=3)=[O:18]

参加物

3

反応物 2

HCID 44603462N-(4-Aminophenyl)-4-fluoro-2-trifluoromethyl-benzamideHCID 698106731-Chloro-N-(2-(dimethylamino)ethyl)-6-oxo-5,6-dihydrobenzo[c][1,8]naphthyridine-9-carboxamide

生成物 1

HCID 44206389N-(2-(Dimethylamino)ethyl)-1-(4-(4-fluoro-2-(trifluoromethyl)benzamido)phenyl amino)-6-oxo-5,6-dihydrobenzo[c][1,8]naphthyridine-9-carboxamide収率 50%

実験手順

The title compound was synthesized according to the procedure described for the preparation of Example 267 using 296 (40 mg, 0.12 mmol), and N-(4-aminophenyl)-4-fluoro-2-(trifluoromethyl)benzamide (36 mg, 0.12 mmol) to provide 297 (35 mg, 50% yield) as a solid. LC-MS (M+H=607, obsd.=607).

後処理

  1. customThe title compound was synthesized

出典と根拠

ORDレコード
ord-e5d4e2cf153f4565b593f32fa5ddc68e
出典データセット
uspto-grants-2014_05
特許番号
US08735584B2

反応ノート

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