alpha-Bromo-2-nitrotoluene → HCID 58168154、化合物
反応式
[NH2:1][C:2]1[CH:16]=[CH:15][C:5]2[C:6](=[O:14])[NH:7][C:8]3[C:13]([C:4]=2[CH:3]=1)=[CH:12][CH:11]=[CH:10][N:9]=3.[N+:17]([C:20]1[CH:27]=[CH:26][CH:25]=[CH:24][C:21]=1[CH2:22]Br)([O-:19])=[O:18]>>[N+:17]([C:20]1[CH:27]=[CH:26][CH:25]=[CH:24][C:21]=1[CH2:22][NH:1][C:2]1[CH:16]=[CH:15][C:5]2[C:6](=[O:14])[NH:7][C:8]3[C:13]([C:4]=2[CH:3]=1)=[CH:12][CH:11]=[CH:10][N:9]=3)([O-:19])=[O:18]参加物
3
実験手順
The title compound was synthesized according to the procedure described for the preparation of Example 458 using 70 (121 mg, 0.57 mmol) and 2-nitro-benzyl bromide (118 mg, 0.69 mmol) to provide 466 (24 mg, 12% yield) as a white powder. LC-MS (M+H=347, obsd.=347). 1H NMR (400 MHz, DMSO-D6) δ 8.56 (d, J=6.6, 1H), 8.41 (d, J=3.1, 1H), 8.07 (dd, J=8.3, 15.1, 2H), 7.51 (dt, J=6.5, 14.0, 2H), 7.43 (d, J=1.9, 1H), 7.35 (dd, J=4.7, 7.9, 1H), 7.03 (d, J=7.6, 1H), 6.91 (dd, J=2.0, 8.7, 1H), 6.25 (s, 2H), 5.89 (s, 2H).
後処理
- customThe title compound was synthesized